That was confirmed after the defeat to a resurgent Dortmund, which was followed by a four-goal loss by Manchester City in the Spanish club's last home game in Group G. Fans chanted Lopetegui's name as he left the pitch.
Associations and contested by top-division European clubs, deciding the competition winners through a round robin group stage to qualify for a double-legged knockout format, and a single leg final
Erling Haaland was only needed on the pitch in the first half but still scored twice in Man City's regular defeat this season, 5-0 at home to Copenhagen.
Now five goals in three Champions League games and a total of 19 in 12 club games for the tireless Norwegian striker.
Madrid coach Julen Lopetegui was sacked by Sevilla minutes after the 4-1 home defeat by Borussia Dortmund.
First-half goals from two young Brazilian forwards, Rodrigo and Vinicius Junior, give Shakhtar a five-point lead in Group F ahead of their second leg in Poland next week.